IL-32 Antibody
Product Specifications
Background
IL-32 Antibody: Interleukin-32 (IL-32) was initially identified as a transcript (NK4) that is selectively expressed in lymphocytes and NK cells and whose expression is increased following activation by IL-2. It was later re-isolated from an IL-18-treated lung carcinoma cell line and re-named IL-32. IL-32 is unusual in that it does not share sequence homology with known cytokine families and is highly expressed in immune tissues, existing in at least four differentially spliced isoforms. Because treatment of human monocytic and mouse macrophage cells with IL-32 induces several proinflammatory cytokines such as TNF-α , IL-8 and MIP-2, and because it is also induced in human peripheral lymphocyte cells after mitogen stimulation and in epithelial cells by IFNγ , it has been suggested that IL-32 may play a role in autoimmune and inflammatory diseases such as rheumatoid arthritis.
NCBI Gene ID
9235
Swiss Prot
P24001
Accession Number
AAH09401
Host
Rabbit
Reactivity
Human
Immunogen
3749
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Recombinant Protein Test (Figure 1) : Anti-IL-32 antibodies (3749) detected human IL-32 recombinant protein at different concentrations.
Recombinant Protein Test3749
Field of Research
Signal Transduction, Cancer
Purification
IL-32 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
IL-32 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-32 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=3749
Fragment
IgG
Specificity
This antibody detects all isoforms of IL-32.
Isoform
Human IL-32 has 7 isoforms, including isoform 1 (234aa, 27kD), isoform 2 (188aa, 22kD), isoform 3 (178aa, 21kD), isoform 4 (131aa, 15kD), isoform 5 (168aa, 19kD), isoform 6 (179aa, 21kD) and isoform 7 (148aa, 17kD) . 3749 can detect all human isoforms.
Symbol
IL32
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Interleukin 32
NCBI Organism
Homo sapiens
Background Reference 01
Dahl et al. J. Immunol. 1992; 148:597-603.
Background Reference 02
Kim et al. Immunity 2005; 22:131-42.
Background Reference 03
Cagnard et al. Eur. Cyto. Network 2005; 16:289-92.
Other Product Names
IL-32 Antibody: NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd, IL-32beta, IL-32alpha, IL-32delta, IL-32gamma, NK4, Interleukin-32, Natural killer cells protein 4, IL-32
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
14424787
Physical Properties
Liquid
Available Sizes
Curated Selection
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