What is the catalog number for XBP-1 Antibody?

The catalog number for XBP-1 Antibody is 3687.

What sizes are available for XBP-1 Antibody?

XBP-1 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does XBP-1 Antibody come in?

XBP-1 Antibody is available in 2 different pack sizes.

Is XBP-1 Antibody in stock?

XBP-1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.

XBP-1 Antibody

Product Specifications

Background

XBP-1 Antibody: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) . Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.

NCBI Gene ID

7494

Swiss Prot

P17861

Accession Number

P17861

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

3687

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

KO Validation (Figure 2) : XBP-1 expression detected by anti-XBP-1 antibodies was observed in wild type HeLa cells, but not in the XBP-1 knockout HeLa cells. KO Validation Recombinant Protein Test (Figure 3) : Anti-XBP-1 antibodies (3687) detected human XBP-1 recombinant protein at different concentrations. Recombinant Protein Test3687

Field of Research

Signal Transduction, Chemokines & Cytokines

Purification

XBP-1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1414 – Mouse Pancreas Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

Buffer

XBP-1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

XBP-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Human XBP-1 has two isoforms, including isoform 1 (261aa, 29kD) and isoform 2 (376aa, 40kD) . Mouse XBP-1 also has two isoforms, including isoform 1 (267aa, 29.6kD) and isoform 2 (371aa, 40kD) . And Rat XBP-1 has two isoforms as well, including isoform 1 (267aa, 30kD) and isoform 2 (371aa, 40kD) . 3687 can detect human, mouse and rat.

Symbol

XBP1

Positive Control 2

Cat. No. 1464 – Rat Liver Tissue Lysate

NCBI Official Name

X-box binding protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Yoshida et al. Cell 2001; 107:881-91.

Background Reference 02

Calfon et al. Nature 2002; 415:92-6.

Background Reference 03

Haze et al. Mol. Cell. Biol. 1999; 10:3787-99.

Background Reference 04

Little et al. Crit. Rev. Eukaryot. Gene Expr. 1994; 4:1-18.

Citation 01

PMID:19363290

Citation 02

PMID: 19808675

Other Product Names

XBP-1 Antibody: XBP2, TREB5, XBP-1, XBP2, X-box-binding protein 1, Tax-responsive element-binding protein 5

Tested Applications

ELISA, WB, ICC, IHC-P, IF

Protein ID

60416406

Physical Properties

Liquid

Available Sizes

Frequently Asked Questions

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