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CTRP5 Antibody

Product Specifications

Background

CTRP5 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. CTRP5 has been suggested to be involved in age-related macular degeneration.

NCBI Gene ID

114902

Swiss Prot

Q9BXJ0

Accession Number

AAQ88749

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

CTRP5 Antibody is immunoaffinity purified IgG.

Positive Control

Cat. No. 1223 - Caco-2 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rat: (93%), Mouse: (93%)

Buffer

CTRP5 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CTRP5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=3573

Fragment

IgG

Specificity

Adipokine proteins are often highly modified post-translationally and migrate in SDS-PAGE at positions other than their predicted size.

Symbol

C1QTNF5

NCBI Official Name

C1q and tumor necrosis factor related protein 5

NCBI Organism

Homo sapiens

Background Reference 01

CTRP5 antibody can be stored at 4˚ C, stable for one year. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 2005; 115:911-9.

Background Reference 02

Tsao T-S, Lodish HF, and Fruebis J. ACRP30, a new hormone controlling fat and glucose metabolism. Euro. J. Pharmacol. 2002; 440:213-21.

Background Reference 03

Wong GW, Wang J, Hug C, et al. A family of Acrp30/ adiponectin structural and functional paralogs. Proc. Natl. Acad. Sci. USA 2004; 101:10302-7.

Background Reference 04

Shapiro L and Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol. 1998; 8:335-8.

Other Product Names

CTRP5 Antibody: CTRP5, CTRP5, UNQ303/PRO344, Complement C1q tumor necrosis factor-related protein 5

Tested Applications

ELISA, WB

Protein ID

37181891

Physical Properties

Liquid

Available Sizes

Curated Selection

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