What is the catalog number for RPS6K1 Antibody?

The catalog number for RPS6K1 Antibody is 3511.

What sizes are available for RPS6K1 Antibody?

RPS6K1 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does RPS6K1 Antibody come in?

RPS6K1 Antibody is available in 2 different pack sizes.

Is RPS6K1 Antibody in stock?

RPS6K1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

RPS6K1 Antibody

Product Specifications

Background

RPS6K1 Antibody: Ribosomal protein S6 kinase 1 (RPS6K1) is the best characterized effector of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. Nutrients and growth factors stimulate a complex including TOR, raptor (regulatory associated protein of TOR), and GbetaL to phosphorylate RPS6K1 and the eukaryotic initiation factor 4E binding protein (4EBP1), leading to increased protein synthesis and cell growth. RPS6K1 is thought to desensitize tissues to insulin as mice deficient in RPS6K1 have been shown to be hypersensitive to insulin and impervious to obesity-induced insulin resistance seen in wild type obese mice.

NCBI Gene ID

6195

Swiss Prot

Q15418

Accession Number

AAC82497

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

RPS6K1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1205 - Jurkat Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rat: (100%), Chicken: (100%), Mouse: (100%)

Buffer

RPS6K1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

RPS6K1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

RPS6KA1

Positive Control 2

Cat. No. 17-005 - Jurkat Cell Slide

NCBI Official Name

Ribosomal protein S6 kinase, 90kDa, polypeptide 1

NCBI Organism

Homo sapiens

Background Reference 01

Burnett PE, Barrow RK, Cohen NA, et al. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. USA. 1998; 95:1432-7.

Background Reference 02

Inoki K, Ouyang H, Li Y, et al. Signaling by target of rapamycin proteins in cell growth control. Microbiol. Mol. Biol. Rev. 2005; 69:79-100.

Background Reference 03

Manning BD. Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis. J. Cell Biol. 2004; 167:399-403.

Background Reference 04

Um SH, Frigerio F, Watanabe M, et al. Absences of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 2004; 431:200-5.