What is the catalog number for Caspase-8 Antibody?

The catalog number for Caspase-8 Antibody is 3473.

What sizes are available for Caspase-8 Antibody?

Caspase-8 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does Caspase-8 Antibody come in?

Caspase-8 Antibody is available in 2 different pack sizes.

Is Caspase-8 Antibody in stock?

Caspase-8 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Caspase-8 Antibody

Product Specifications

Background

Caspase-8 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex. The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation. FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis.

NCBI Gene ID

841

Swiss Prot

Q14790

Accession Number

NP_001219

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Neuroscience, Autophagy, Cancer, Inflammasomes

Purification

Caspase-8 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1205 - Jurkat Cell Lysate

Concentration

1 mg/mL

Buffer

Caspase-8 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Caspase-8 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

55 kDa

Fragment

IgG

Specificity

Depending on cell lines or tissues used, either full-length or other cleavage products may be observed.

Symbol

CASP8

Positive Control 2

Cat. No. 1306 - Human Spleen Tissue Lysate

Positive Control 3

Cat. No. 1406 - Mouse Spleen Tissue Lysate

Positive Control 4

Cat. No. 1466 - Rat Spleen Tissue Lysate

Positive Control 5

Cat. No. 10-901 - Human Spleen Tissue Slide

Positive Control 6

Cat. No. 17-005 - Jurkat Cell Slide

NCBI Official Name

Caspase 8, apoptosis-related cysteine peptidase

NCBI Organism

Homo sapiens

Background Reference 01

Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.

Background Reference 02

Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.

Background Reference 03

Wolf BB and Green DR. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 1999; 274:20049-52.

Background Reference 04

Muzio M, Chinnaiyan AM, Kischkel FC, et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 1996; 85:817-27.