Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Caspase-5 Antibody

Product Specifications

Background

Caspase-5 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18. Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1β . Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-gamma.

NCBI Gene ID

838

Swiss Prot

P51878

Accession Number

P51878

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Inflammasomes

Purification

Caspase-5 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1225 - Ramos Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (79%)

Buffer

Caspase-5 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Caspase-5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=3457

Fragment

IgG

Specificity

Depending on cell lines or tissues used, other cleavage products may be observed.

Symbol

CASP5

Positive Control 2

Cat. No. 1286 - P815 Cell Lysate

Positive Control 3

Cat. No. 17-206 - P815 Cell Slide

NCBI Official Name

Caspase 5, apoptosis-related cysteine peptidase

NCBI Organism

Homo sapiens

Background Reference 01

Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.

Background Reference 02

Kuida K, Lippke JA, Ku G, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 β converting enzyme. Science 1995; 267:2000-3.

Background Reference 03

Gracie JA, Robertson SE, and McInnes IB. Interleukin-18. J. Leukoc. Biol. 2003; 73:213-224.

Background Reference 04

Martinon F, Burns K, and Tschopp J. The inflammasome: a molecular platform triggering activation of the inflammatory caspases and processing of proIL-1beta. Mol. Cell. 2002; 10:417-26.

Other Product Names

Caspase-5 Antibody: ICH-3, ICEREL-III, ICE (rel) III, ICH3, Caspase-5, Protease ICH-3, CASP-5

Tested Applications

ELISA, WB, ICC, IF

Protein ID

212276423

Physical Properties

Liquid

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Recombinant Human ACBD6 Protein, His, E.coli-5ug
QP10938-5ug 5ug

Recombinant Human ACBD6 Protein, His, E.coli-5ug

Ask
View Details
Rabbit anti-Saccharomyces cerevisiae (strain 204508/S288c)(Baker's yeast) SPT10 Polyclonal Antibody
MBS7156434 Inquire

Rabbit anti-Saccharomyces cerevisiae (strain 204508/S288c)(Baker's yeast) SPT10 Polyclonal Antibody

Ask
View Details
Human EpCAM Protein, Fc Tag
KMPH6122 50 µg

Human EpCAM Protein, Fc Tag

Ask
View Details
MTTP (NM_000253) Human Over-expression Lysate
LH02831V 100 µg

MTTP (NM_000253) Human Over-expression Lysate

Ask
View Details