BTK Antibody

Product Specifications

Background

BTK Antibody: Bruton's tyrosine kinase (BTK) was initially identified as a member of the src family for protein-tyrosine kinases that was involved in X-linked agamma-globulinaemia, and has since been shown to involved in a number of signaling pathways in hemapoietic lineage. It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9. The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens. BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction.

NCBI Gene ID

695

Swiss Prot

Q06187

Accession Number

Q06187

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

BTK Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1215 - U937 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Chicken: (100%)

Buffer

BTK Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

BTK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

Multiple isoforms of BTK are known to exist.

Symbol

BTK

Positive Control 2

Cat. No. 1224 - Daudi Cell Lysate

NCBI Official Name

Bruton agammaglobulinemia tyrosine kinase

NCBI Organism

Homo sapiens

Background Reference 01

Vetrie D, Vorechovsky I, Sideras P, et al. The gene involved in X-linked aγ globulinaemia is a member of the src family of tyrosine kinases. Nature 1993; 361:226-33.

Background Reference 02

Kawakami Y, Kitaura J, Hata D, et al. Functions of Bruton's tyrosine kinase in mast and B cells. J. Leukoc. Biol. 1999; 65 (3) :286-90.

Background Reference 03

Jefferies CA, Doyla S, Brunner C, et al. Bruton's tyrosine kinase is a Toll/Interleukin-1 receptor domain-binding protein that participates in nuclear factor kB activation by Toll-like receptor 4. J. Biol. Chem. 2003; 278:26258-26264.