What is the catalog number for TAB3 Antibody?

The catalog number for TAB3 Antibody is 3391.

What sizes are available for TAB3 Antibody?

TAB3 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does TAB3 Antibody come in?

TAB3 Antibody is available in 2 different pack sizes.

Is TAB3 Antibody in stock?

TAB3 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

TAB3 Antibody

Product Specifications

Background

TAB3 Antibody: TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.

NCBI Gene ID

257397

Swiss Prot

Q8N5C8

Accession Number

NP_690000

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Autophagy

Purification

TAB3 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 10-401 - Human Kidney Tissue Slide

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Mouse: (92%)

Buffer

TAB3 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TAB3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

TAB3 antibody is human specific. TAB3 antibody is predicted not to cross-react with other TAB proteins.

Symbol

TAB3

NCBI Official Name

TGF-beta activated kinase 1/MAP3K7 binding protein 3

NCBI Organism

Homo sapiens

Background Reference 01

Cheung PC, Nebreda AR, and Cohen P. TAB3, a new binding partner of the protein kinase TAK1. Biochem. J. 2004; 378:27-34.

Background Reference 02

Besse A, Lamothe B, Campos AD, et al. TAK1-dependent signaling requires functional interaction with TAB2/TAB3. J. Biol. Chem. 2007; 282:3918-28.

Background Reference 03

Criollo A, Niso-Santano M, Malik SA, et al. Inhibition of autophagy by TAB2 and TAB3. EMBO J. 2011; 30:4908-20.

Other Product Names

TAB3 Antibody: NAP1, MAP3K7IP3, TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, TAB-3