What is the catalog number for OMI Antibody?

The catalog number for OMI Antibody is 3319.

What sizes are available for OMI Antibody?

OMI Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does OMI Antibody come in?

OMI Antibody is available in 2 different pack sizes.

Is OMI Antibody in stock?

OMI Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

OMI Antibody

Product Specifications

Background

OMI Antibody: Inhibitor of apoptosis proteins (IAPs) were initially identified in baculoviruses as proteins that inhibit apoptosis of the host cells to allow time for viral replication. Cellular homologues containing at least one baculoviral IAP repeat (BIR) motif essential for their anti-apoptosis activity have been identified in yeasts and higher organisms and often act by binding and inhibiting processed caspases. The activity of these proteins can be modulated by the expression of proteins such as Smac/DIABLO and XAF-1 which displace or prevent the binding of caspases by IAPs. Recently, a mitochondrial serine protease termed Omi/HtrA2 has been found to bind IAPs. Similar to Smac, Omi possesses a conserved IAP-binding motif, but acts to cleave IAPs to irreversibly inactivate IAPs and promote apoptosis.

NCBI Gene ID

27429

Swiss Prot

O43464

Accession Number

AAB94569

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Immunology

Purification

OMI Antibody is Ion exchange chromatography purified.

Positive Control

Cat. No. 1320 - Human Colon Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Mouse: (85%), Bovine: (90%)

Buffer

OMI Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

OMI antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

HTRA2

NCBI Official Name

HtrA serine peptidase 2

NCBI Organism

Homo sapiens

Background Reference 01

Crook NE, Clem RJ, and Miller LK. An apoptosis inhibiting baculovirus gene with a zinc finger like motif. J. Virol. 1993; 67:2168-2174.

Background Reference 02

Liston P, Fong WG, and Korneluk RG. The inhibitors of apoptosis: there is more to life than Bcl2. Oncogene 2003; 22:8568-80.

Background Reference 03

Vaux DL and Silke J. Mammalian mitochondrial IAP binding proteins. Biochem. Biophys. Res. Comm. 2003; 304:499-504.

Background Reference 04

Suzuki Y, Imai Y, Nakayama H, et al. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol. Cell 2001; 8:613-21.