TIRP Antibody

Product Specifications

Background

TIRP Antibody: TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) . TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF) -6, and ultimately the activation of NF-κ B. Expression of TIRP appears to be essential for TLR4 signalling.

NCBI Gene ID

353376

Swiss Prot

Q86XR7

Accession Number

AAP81748

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

TIRP Antibody is Ion exchange chromatography purified.

Positive Control

Cat. No. 1324 - Human Kidney Tissue Lysate

Concentration

1 mg/mL

Buffer

TIRP Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TIRP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

TICAM2

Positive Control 2

Cat. No. 1405 - Mouse Kidney Tissue Lysate

Positive Control 3

Cat. No. 1465 - Rat Kidney Tissue Lysate

NCBI Official Name

Toll-like receptor adaptor molecule 2

NCBI Organism

Homo sapiens

Background Reference 01

O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003;24:286-9.

Background Reference 02

Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003;3:466-77.