MD-2 Antibody

Product Specifications

Background

MD-2 Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) . TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.

NCBI Gene ID

23643

Swiss Prot

Q9Y6Y9

Accession Number

NP_056179

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

3289

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Recombinant Protein Test (Figure 1) : Anti-MD-2 antibodies (3289) detected human MD-2 recombinant protein at different concentrations. Recombinant Protein Test3289

Field of Research

Innate Immunity

Purification

MD-2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1406 - Mouse Spleen Tissue Lysate

Concentration

1 mg/mL

Buffer

MD-2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

MD-2 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Human MD-2 has 2 isoforms, including isoform 1 (160aa, 18kD) and isoform 2 (130aa, 15kD) . Mouse MD-2 has one isoform (160aa, 18kD) and Rat MD-2 also has one isoform (160aa, 18kD) . 3289 can detect human, mouse and rat.

Symbol

LY96

Positive Control 2

Cat. No. 1466 - Rat Spleen Tissue Lysate

Positive Control 3

Cat. No. 10-901 - Human Spleen Tissue Slide

NCBI Official Name

Lymphocyte antigen 96

NCBI Organism

Homo sapiens

Background Reference 01

O'Neill et al. Trends in Imm. 2003; 24:286-9.

Background Reference 02

Vogel. Mol. Interv. 2003; 3:466-77.

Background Reference 03

Takeda et al. Annu. Rev. Immunol. 2003; 21:335-76.

Background Reference 04

Janeway et al. Annu. Rev. Immunol. 2002; 20:197-216.

Other Product Names

MD-2 Antibody: MD2, MD-2, ly-96, ESOP-1, ESOP1, MD2, Lymphocyte antigen 96, Ly-96

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

223555998

Physical Properties

Liquid

Available Sizes

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