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TLR11 Antibody

Product Specifications

Background

TLR11 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR11 is one of three mouse TLRs that lack a human ortholog. It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system.

NCBI Gene ID

239081

Swiss Prot

Q6R5P0

Accession Number

NP_991388

Host

Rabbit

Reactivity

Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

TLR11 Antibody is Ion exchange chromatography purified.

Positive Control

Cat. No. 1283 - RAW 264.7 Cell Lysate

Concentration

1 mg/mL

Buffer

TLR11 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TLR11 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=3277

Fragment

IgG

Symbol

Tlr11

Positive Control 2

Cat. No. 17-203 - RAW 264.7 Cell Slide

NCBI Official Name

Toll-like receptor 11

NCBI Organism

Mus musculus

Background Reference 01

Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.

Background Reference 02

Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.

Background Reference 03

Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.

Background Reference 04

O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.

Other Product Names

TLR11 Antibody: Gm287, Gm287, Toll-like receptor 11

Tested Applications

ELISA, WB, ICC, IF

Protein ID

45429992

Physical Properties

Liquid

Available Sizes

Curated Selection

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