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Caspase-12 Antibody (Large)

Product Specifications

Background

Caspase-12 Antibody: (Large) Three distinct signaling pathways lead to programmed cell death (apoptosis) . The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP) . Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

NCBI Gene ID

12364

Swiss Prot

O08736

Accession Number

CAA73532

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer

Purification

Caspase-12 (Large) Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1301 - Human Heart Tissue Lysate

Concentration

1 mg/mL

Buffer

Caspase-12 Antibody is supplied in PBS containing 0.02% sodium azide. (Large)

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Caspase-12 (Large) antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=3195

Fragment

IgG

Specificity

Caspase-12 (large) antibody is predicted to have no cross reactivity to other members in the caspase family.

Symbol

Casp12

Positive Control 2

Cat. No. 1401 - Mouse Heart Tissue Lysate

Positive Control 3

Cat. No. 10-501 - Human Heart Tissue Slide

Positive Control 4

Cat. No. 1461 - Rat Heart Tissue Lysate

NCBI Official Name

Caspase 12

NCBI Organism

Mus musculus

Background Reference 01

Nakagawa T, Zhu H, Morishima N, et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β . Nature 2000; 403:98-103.

Background Reference 02

Mehmet H. Caspases find a new place to hide. Nature 2000; 403:29-30

Background Reference 03

Van de Craen M, Vandenabeele P, Declercq W, et al. Characterization of seven murine caspase family members. FEBS Lett. 1997; 403:61-9

Other Product Names

Caspase-12 (Large) Antibody: Caspase-12, CASP-12

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

2094806

Physical Properties

Liquid

Available Sizes

Curated Selection

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