What is the catalog number for TIRAP Antibody?

The catalog number for TIRAP Antibody is 3155.

What sizes are available for TIRAP Antibody?

TIRAP Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does TIRAP Antibody come in?

TIRAP Antibody is available in 2 different pack sizes.

Is TIRAP Antibody in stock?

TIRAP Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.

Is this product suitable for live cell imaging?

Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.

TIRAP Antibody

Product Specifications

Background

TIRAP Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-κ B and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.

NCBI Gene ID

114609

Swiss Prot

P58753

Accession Number

AAL05627

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

TIRAP Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1219 - MCF7 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Mouse: (90%)

Buffer

TIRAP Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TIRAP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

TIRAP

Positive Control 2

Cat. No. 1301 - Human Heart Tissue Lysate

Positive Control 3

Cat. No. 10-501 - Human Heart Tissue Slide

NCBI Official Name

Toll-interleukin 1 receptor (TIR) domain containing adaptor protein

NCBI Organism

Homo sapiens

Background Reference 01

Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.