PHAP I Antibody

Product Specifications

Background

PHAP I Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.

NCBI Gene ID

8125

Swiss Prot

P39687

Accession Number

P39687

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

3151

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis

Purification

PHAP I Antibody is DEAE purified.

Positive Control

Cat. No. 1207 - Raji Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (85%)

Buffer

PHAP I Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PHAP I antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

This polyclonal antibody has no cross-reaction to PHAP I2a and PHAP III.

Symbol

ANP32A

Positive Control 2

Cat. No. 1416 - Mouse Testis Tissue Lysate

Positive Control 3

Cat. No. 1476 - Rat Testis Tissue Lysate

Positive Control 4

Cat. No. 1408 - Mouse Small Intestine Tissue Lysate

NCBI Official Name

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A

NCBI Organism

Homo sapiens

Background Reference 01

Jiang et al. Science. 2003;299 (5604) :223-6.

Background Reference 02

Nicholson and Thornberry. Science. 2003 10;299 (5604) :214-5.

Citation 01

16489023

Citation 02

23652204

Citation 03

Parrish. Regulation of Apoptosis Following Mitochondrial Cytochrome c Release. Department of Pharmacology and Molecular Cancer Biology, Duke University. PhD Thesis, 2010.

Other Product Names

PHAP I Antibody: LANP, MAPM, PP32, HPPCn, PHAP1, PHAPI, I1PP2A, C15orf1, LANP, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32