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PHAP III Antibody

Product Specifications

Background

PHAP III Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.

NCBI Gene ID

81611

Swiss Prot

Q9BTT0

Accession Number

NP_112182

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis

Purification

PHAP III Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1203 - A549 Cell Lysate

Concentration

1 mg/mL

Buffer

PHAP III Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PHAP III antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures..

Calculated Molecular Weight

35 kDa

Fragment

IgG

Specificity

PHAP III has no cross-reaction to PHAP I and PHAP I2a.

Symbol

ANP32E

Positive Control 2

Cat. No. 1211 - HepG2 Cell Lysate

Positive Control 3

Cat. No. 1308 - Human Small Intestine Tissue Lysate

Positive Control 4

Cat. No. 11-801 - Human Small Intestine Tissue Slide

NCBI Official Name

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

NCBI Organism

Homo sapiens

Background Reference 01

Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC , Rosenberg S, Wang X. Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science. 2003;299 (5604) :223-6.

Background Reference 02

Nicholson DW, Thornberry NA. Apoptosis. Life and death decisions. Science. 2003 10;299 (5604) :214-5.

Other Product Names

PHAP III Antibody: LANPL, LANP-L, Acidic leucine-rich nuclear phosphoprotein 32 family member E, LANP-like protein

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

13569879

Physical Properties

Liquid

Available Sizes

Frequently Asked Questions

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