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BAFF Receptor Antibody

Product Specifications

Background

BAFF Receptor Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-κ B and c-jun N-terminal kinase.

NCBI Gene ID

115650

Swiss Prot

Q96RJ3

Accession Number

AAK91826

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Chemokines & Cytokines

Purification

BAFF Receptor Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1306 - Human Spleen Tissue Lysate

Concentration

1 mg/mL

Buffer

BAFF Receptor Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

BAFF Receptor antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=3097

Calculated Molecular Weight

20 kDa

Fragment

IgG

Symbol

TNFRSF13C

Positive Control 2

Cat. No. 1406 - Mouse Spleen Tissue Lysate

Positive Control 3

Cat. No. 1466 - Rat Spleen Tissue Lysate

Positive Control 4

Cat. No. 1315 - Human Tonsil Tissue Lysate

Positive Control 5

Cat. No. 10-901 - Human Spleen Tissue Slide

NCBI Official Name

Tumor necrosis factor receptor superfamily, member 13C

NCBI Organism

Homo sapiens

Background Reference 01

Moore PA, Belvedere O, Orr A, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999;285:260-3

Background Reference 02

Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999;189:1747-56

Background Reference 03

Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol 1999;65:680-3

Background Reference 04

Mukhopadhyay A, Ni J, Zhai Y, Yu GL, Aggarwal BB. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-κ B, and c-Jun NH2-terminal kinase. J Biol Chem 1999 ;274:15978-81

Other Product Names

BAFF Receptor Antibody: BAFFR, CD268, CVID4, BAFF-R, BROMIX, prolixin, BAFFR, BR3, Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

15208475

Physical Properties

Liquid

Available Sizes

Curated Selection

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