ARTS Antibody
Product Specifications
Background
ARTS Antibody: Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-beta signaling pathway. ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-beta and, to a lesser extent, by other apoptotic agents, such as TNF-α and Fas ligand.
NCBI Gene ID
5414
Swiss Prot
O43236
Accession Number
AAG45673
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
ARTS Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1302 - Human Lung Tissue Lysate
Concentration
1 mg/mL
Buffer
ARTS Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ARTS antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=3025
Calculated Molecular Weight
32 kDa
Fragment
IgG
Symbol
SEPT4
Positive Control 2
Cat. No. 1306 - Human Spleen Tissue Lysate
Positive Control 3
Cat. No. 1305 - Human Kidney Tissue Lysate
Positive Control 4
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
Septin 4
NCBI Organism
Homo sapiens
Background Reference 01
Larisch S, Yi Y, Lotan R, Kerner H, et al. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nat Cell Biol 2000;2 (12) :915-21
Background Reference 02
Depraetere V. The ARTS of apoptosis. Nat Cell Biol. 2000;2 (12) :E219.
Background Reference 03
Paavola, P., Horelli-Kuitunen, N., Palotie, A. and Peltonen, L. Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene. Genomics 1999;55 (1) :122-125
Background Reference 04
Zieger, B., Tran, H., Hainmann, I. , Wunderle, D., Zgaga-Griesz, A., Blaser, S. and Ware, J. Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2. Gene 2000;261 (2) :197-203
Other Product Names
ARTS Antibody: H5, ARTS, MART, SEP4, CE5B3, PNUTL2, hucep-7, BRADEION, hCDCREL-2, Septin-4, Apoptosis-related protein in the TGF-beta signaling pathway
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
12024871
Physical Properties
Liquid
Available Sizes
Curated Selection
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