KappaB ras1 Antibody

KappaB ras1 Antibody: KappaB ras-1 (κ B-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with Iκ B (Iκ B), an inhibitor of the transcription factor NF-κ B. Iκ B exists in two homologous forms, Iκ B-alpha and Iκ B-beta, although Iκ B-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive Iκ B-alpha-NF-κ B complexes can shuttle in and out of the nucleus, Iκ B-beta-NF-κ B complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the Iκ B-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of Iκ B-beta and regulating the rate of degradation of Iκ B-beta. This antibody is specific for kappaB-ras1 and has no cross-reactivity to kappaB-ras2.

KappaB ras1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Chen Y, Wu J and Ghosh G. KappaB-Ras binds to the unique insert within the ankyrin repeat domain if IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes. J. Biol. Chem.2003; 278:23101-6.

KappaB ras1 Antibody: KBRAS1, kappaB-Ras1, KBRAS1, NF-kappa-B inhibitor-interacting Ras-like protein 1, I-kappa-B-interacting Ras-like protein 1, Kappa B-Ras protein 1