KappaB ras Antibody

Product Specifications

Background

KappaB ras Antibody: KappaB ras-1 (κ B-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with Iκ B (Iκ B), an inhibitor of the transcription factor NF-κ B. Iκ B exists in two homologous forms, Iκ B-alpha and Iκ B-beta, although Iκ B-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive Iκ B-alpha-NF-κ B complexes can shuttle in and out of the nucleus, Iκ B-beta-NF-κ B complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the Iκ B-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of Iκ B-beta and regulating the rate of degradation of Iκ B-beta. This antibody detects both kappaB-ras1 and kappaB-ras2.

NCBI Gene ID

28512

Swiss Prot

Q9NYS0

Accession Number

AAF34998

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

KappaB ras Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1283 - RAW 264.7 Cell Lysate

Concentration

1 mg/ml

Homology

Predicted species reactivity based on immunogen sequence: Chicken: (94%)

Buffer

KappaB ras Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

KappaB ras antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

NKIRAS1

Positive Control 2

Cat. No. 1369 - Human Lymph node Tissue Lysate

Positive Control 3

Cat. No. 11-521 - Human Lymphoid Tissue Tissue Slide

NCBI Official Name

NFKB inhibitor interacting Ras-like 1

NCBI Organism

Homo sapiens

Background Reference 01

Fenwick C, Na SY, Voll RE, et al. A subclass of Ras proteins that regulate the degradation of IkappaB. Science 2000; 287:869-73.

Background Reference 02

Chen Y, Wu J and Ghosh G. KappaB-Ras binds to the unique insert within the ankyrin repeat domain if IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes. J. Biol. Chem.2003; 278:23101-6.

Other Product Names

KappaB ras Antibody: KBRAS1, kappaB-Ras1, KBRAS1, NF-kappa-B inhibitor-interacting Ras-like protein 1, I-kappa-B-interacting Ras-like protein 1, Kappa B-Ras protein 1