IL-21 Receptor Antibody

Product Specifications

Background

IL-21 Receptor Antibody: A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling. Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.

NCBI Gene ID

50615

Swiss Prot

Q9HBE5

Accession Number

NP_068570

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Chemokines & Cytokines

Purification

IL-21 Receptor Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1207 - Raji Cell Lysate

Concentration

1 mg/ml

Buffer

IL-21 Receptor Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

IL-21 Receptor antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

60 kDa

Fragment

IgG

Symbol

IL21R

NCBI Official Name

Interleukin 21 receptor

NCBI Organism

Homo sapiens

Background Reference 01

Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000;408 (6808) :57-63.

Background Reference 02

Ozaki K, Kikly K, Michalovich D, et al. Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain. Proc Natl Acad Sci USA. 2000;97 (21) :11439-44.