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Noxa Antibody

Product Specifications

Background

Noxa Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.

NCBI Gene ID

58801

Swiss Prot

Q9JM54

Accession Number

NP_067426

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer

Purification

Noxa Antibody is immunoaffinity chromatography purified IgG.

Positive Control

Cat. No. 1319 - Human Stomach Tissue Lysate

Concentration

1 mg/mL

Buffer

Noxa Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Noxa antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=2437

Fragment

IgG

Symbol

Pmaip1

Positive Control 2

Cat. No. 10-801 - Human Stomach Tissue Slide

NCBI Official Name

Phorbol-12-myristate-13-acetate-induced protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Oda E, Ohki R, Murasawa H, et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000; 288:1053-8.

Background Reference 02

Nakano K and Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 2001; 7:683-94.

Background Reference 03

Yu J, Zhang L, Hwang PM, et al. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 2001; 7:673-82.

Background Reference 04

Eferl R, Ricci R, Kenner L, et al. Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell 2003; 112:181-92.

Other Product Names

Noxa Antibody: Noxa, Phorbol-12-myristate-13-acetate-induced protein 1

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

10946832

Physical Properties

Liquid

Available Sizes

Curated Selection

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