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BACE2 Antibody

Product Specifications

Background

BACE2 Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) . A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.

NCBI Gene ID

25825

Swiss Prot

Q9Y5Z0

Accession Number

AAF17078

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

BACE2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1301 - Human Heart Tissue Lysate

Concentration

1 mg/mL

Buffer

BACE2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

BACE2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=2247

Fragment

IgG

Symbol

BACE2

Positive Control 2

Cat. No. 1401 - Mouse Heart Tissue Lysate

NCBI Official Name

Beta-site APP-cleaving enzyme 2

NCBI Organism

Homo sapiens

Background Reference 01

Vassar R, et al. β -secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999; 286:735-41.

Background Reference 02

Hussain I, et al. Identification of a novel aspartic protease (Asp 2) as β -secretase. Mol Cell Neurosci 1999; 14:419-27.

Background Reference 03

Sinha S, et al. Purification and cloning of amyloid precursor protein β -secretase from human brain. Nature 1999; 402:537-40.

Background Reference 04

Yan R, et al. Membrane-anchored aspartyl protease with Alzheimer's disease β -secretase activity. Nature 1999; 402:533-7.

Other Product Names

BACE2 Antibody: ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, UNQ418/PRO852, Beta-secretase 2, Aspartic-like protease 56 kDa, ASP1

Tested Applications

ELISA, WB, IHC-P

Protein ID

6561812

Physical Properties

Liquid

Available Sizes

Curated Selection

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