Caspase-13 Antibody

Product Specifications

Background

Caspase-13 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13. Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.

NCBI Gene ID

338039

Swiss Prot

O75601

Accession Number

O75601

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer

Purification

Caspase-13 Antibody is Ion exchange chromatography purified.

Positive Control

Cat. No. 1209 - HL60 Cell Lysate

Concentration

1 mg/ml

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

Buffer

Caspase-13 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Caspase-13 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

43 kDa

Fragment

IgG

Symbol

CASP4

Positive Control 2

Cat. No. 1403 - Mouse Brain Tissue Lysate

Positive Control 3

Cat. No. 1463 - Rat Brain Tissue Lysate

NCBI Official Name

Caspase 4, apoptosis-related cysteine peptidase

NCBI Organism

Bos taurus

Background Reference 01

Humke EW, Ni J, Dixit VM. ERICE, a novel FLICE-activatable caspase. J Biol Chem 1998;273:15702-7 (WD0500)

Other Product Names

Caspase-13 Antibody: CASP13, Caspase-13, Evolutionary related interleukin-1-beta-converting enzyme, CASP-13

Tested Applications

ELISA, WB, IHC-P

Protein ID

10720034

Physical Properties

Liquid

Available Sizes

Curated Selection

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