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RICK Antibody

Product Specifications

Background

RICK Antibody: Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively. RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-κ B and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1β . The messenger RNA of RICK is expressed in multiple human tissues.

NCBI Gene ID

8767

Swiss Prot

O43353

Accession Number

O43353

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis

Purification

RICK Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/ml

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (95%)

Buffer

RICK Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

RICK antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=2075

Fragment

IgG

Symbol

RIPK2

Positive Control 2

Cat. No. 1225 - Ramos Cell Lysate

Positive Control 3

Cat. No. 1287 - EL4 Cell Lysate

Positive Control 4

Cat. No. 1202 - A431 Cell Lysate

Positive Control 5

Cat. No. 1204 - K562 Cell Lysate

Positive Control 6

Cat. No. 17-002 - A-431 Cell Slide

NCBI Official Name

Receptor-interacting serine-threonine kinase 2

NCBI Organism

Homo sapiens

Background Reference 01

Inohara N, del Peso L, Koseki T, et al. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. J. Biol. Chem. 1998; 273:12296-300.

Background Reference 02

McCarthy JV, Ni J, and Dixit VM. RIP2 is a novel NF-κ B-activating and cell death-inducing kinase. J. Biol. Chem. 1998; 273:16968-75.

Background Reference 03

Thome M, Hofmann K, Burns K, et al. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr. Biol. 1998; 8:885-8.

Other Product Names

RICK Antibody: CCK, RICK, RIP2, CARD3, GIG30, CARDIAK, UNQ277/PRO314/PRO34092, CARD-containing interleukin-1 beta-converting enzyme-associated kinase, CARD-containing IL-1 beta ICE-kinase

Tested Applications

ELISA, WB, ICC, IF

Protein ID

20455217

Physical Properties

Liquid

Available Sizes

Curated Selection

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