GFR alpha 3 Antibody

Product Specifications

Background

GFR alpha 3 Antibody: Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRα and Ret receptor tyrosine kinase GFRbeta. Following the findings of GFRα -1 and -2, a novel receptor in GFRα family was identified from human and mouse and designated GFRα -3. GFRα -3 binds persephin, thus, persephin, GFRα -3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.

NCBI Gene ID

14587

Swiss Prot

O35118

Accession Number

NP_034410

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Growth Factors, Neuroscience

Purification

GFR alpha 3 Antibody is DEAE purified.

Positive Control

Cat. No. 1401 - Mouse Heart Tissue Lysate

Concentration

1 mg/ml

Buffer

GFR alpha 3 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

GFR alpha 3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

Gfra3

Positive Control 2

Cat. No. 1404 - Mouse Liver Tissue Lysate

NCBI Official Name

Glial cell line derived neurotrophic factor family receptor alpha 3

NCBI Organism

Mus musculus

Background Reference 01

Milbrandt J, de Sauvage FJ, Fahrner TJ, et al. Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron 1998; 20:245-253.

Background Reference 02

Nomeclature Committee. Nomeclature of GPI-linked receptors for the GDNF ligand family. GFRa. Neuron 1997; 19:485.

Background Reference 03

Jing S, Yu Y, Fang M, et al. GFRα -2 and GFRα -3 are two new receptors for ligands of the DGNF family. J. Biol. Chem. 1997; 272:33111-7.

Background Reference 04

Baloh RH, Gorodinsky A, Golden JP, et al. GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc. Natl. Acad. Sci. USA 1998; 95:5801-6.