GFR alpha 1 Antibody

Product Specifications

Background

GFR alpha 1 Antibody: Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRα -1 recently. GFRα -1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK) . Thus, GDNF, GFRα and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.

NCBI Gene ID

2674

Swiss Prot

P56159

Accession Number

P56159

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Growth Factors, Neuroscience

Purification

GFR alpha 1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1303 - Human Brain Tissue Lysate

Concentration

1 mg/mL

Buffer

GFR alpha 1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

GFR alpha 1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

51 kDa

Fragment

IgG

Specificity

GFR alpha 1 antibody is predicted to not cross-react with other members of the GFR alpha family of proteins.

Symbol

GFRA1

Positive Control 2

Cat. No. 1304 - Human Liver Tissue Lysate

Positive Control 3

Cat. No. 1305 - Human Kidney Tissue Lysate

Positive Control 4

Cat. No. 1306 - Human Spleen Tissue Lysate

Positive Control 5

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

GDNF family receptor alpha 1

NCBI Organism

Homo sapiens

Background Reference 01

Jing S, Wen D, Yu Y, et al. GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-a, a novel receptor for GDNF. Cell 1996; 85:1113-24.

Background Reference 02

Treanor JJS, Goodman L, Sauvage FD, et al. Characterization of a multicomponent receptor for GDNF. Nature 1996;82:80-83.

Background Reference 03

Sanicola M, Hession C, Worley D, et al. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proc. Natl. Acad. Sci. USA 1997; 94:6238-43.

Background Reference 04

Buj-Bello A, Adu J, Pinon LG, et al. Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase. Nature 1997; 387:721-4