NIK Antibody

Product Specifications

Background

NIK Antibody: Nuclear factor kappa B (NF-κ B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα , LPS and mitogens. A serine/threonine protein kinase which mediates NF-κ B activation by IL-1, TNFα and CD95 was identified recently and designated NIK (for NF-κ B inducing kinase) . NIK is an activator of Iκ B kinase alpha and beta (IKKα and IKKβ ) . Therefore, NIK is a key molecule in the NF-κ B signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.

NCBI Gene ID

9020

Swiss Prot

Q99558

Accession Number

Q99558

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

NIK Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1210 - HEK293 Cell Lysate

Concentration

1 mg/ml

Homology

Predicted species reactivity based on immunogen sequence: Mouse: (94%)

Buffer

NIK Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

NIK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.