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Trail Antibody

Product Specifications

Background

Trail Antibody: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. TRAIL (TNF-related apoptosis-inducing ligand) is a type II membrane protein and expressed in a variety of human tissues (1,2) . The death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL (3-6) . Like TNF and Fas ligand, TRAIL induces apoptosis and NF-κ B activation in many tissues and cells.

NCBI Gene ID

8743

Swiss Prot

P50591

Accession Number

NP_003801

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer

Purification

Trail Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/ml

Homology

Predicted species reactivity based on immunogen sequence: Mouse: (82%)

Buffer

Trail Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Trail antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=1113

Fragment

IgG

Symbol

TNFSF10

Positive Control 2

Cat. No. 1303 - Human Brain Tissue Lysate

Positive Control 3

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Tumor necrosis factor (ligand) superfamily, member 10

NCBI Organism

Homo sapiens

Background Reference 01

Wiley SR, Schooley K, Smolak PJ, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995; 3:673-82.

Background Reference 02

Pitti RM, Marsters SA, Ruppert S, et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 1996; 271:12687-90.

Background Reference 03

Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science; 1997; 276:111-3.

Background Reference 04

Schneider P, Thome M, Burns K, et al. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-κ B. Immunity 1997; 7:831-6.

Other Product Names

Trail Antibody: TL2, APO2L, CD253, TRAIL, Apo-2L, Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

4507593

Physical Properties

Liquid

Available Sizes

Curated Selection

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