Γ-GT

Gamma-glutamyl transferase is one of a large group of enzymes known as peptidases. A peptidase is an enzyme that catalyzes the hydrolytic cleavage of peptides to form amino acids or smaller peptides. γ-GT catalyzes the transfer of γ-glutamyl groups from peptides or peptide-like compounds to an acceptor peptide molecule. Although renal tissue has the highest level of γ-GT, the major source of the enzyme present in serum is of hepatic origin. Elevated levels of γ-GT are found in association with hepatobiliary and pancreatic disorders, alcoholics and heavy drinkers, in myocardial disorders and in diabetics.