Lysophosphatidic Acid Receptor 2 (EDG4) CT

Product Specifications

Background

EDG4 (LPA2) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG4 (LPA2) is lysophospholipid. There are 6 known members of the EDG receptor family and they are implicated in mediating growthrelated effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG4 (LPA2) is expressed in testes, ovarian tumor and leukocyte containing tissues.

UniProt

Q9HBW0

Species Reactivity

Human

Conjugation

Unconjugated

Type

Blocking Peptide

Applications

Functional Inhibition

Field of Research

Signal Transduction

Assay Principle

For use with EDG4 (LPA2) (NT) polyclonal antibody (Cat. No. X1570P).

Stability

See expiration date on vial

Concentration

See vial for Concentration

Form

Provided in solution at 1 mg/mL in phosphate buffered saline.

Precautions

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

References & Citations

1. Goetzl EJ and An, S. Diversity of cellular receptors and functions for the lysophospholipid growth factos lysophosphatidic acid and sphingosine 1-phosphate. FASEB J. 1998, 12, 1589-98. 2. An, S., Goetzl, E.J., Lee, H. Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J. Cell Biochem. Suppl. 1998, 30-31, 147-57.