Dequalinium (Chloride)

Dequalinium chloride is an Apamin (HY-P0256) -sensitive potassium channel selective blocker. Dequalinium chloride is a cationic, lipophilic mitochondrial poison. Dequalinium chloride is also an antagonist pf α7 nAChR, and an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity[1][2][3][4].

Product Specifications

CAS Number

[522-51-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bacterial; nAChR; Parasite; Potassium Channel

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/dequalinium-chloride.html

Purity

99.72

Solubility

DMSO : < 1 mg/mL|H2O : 0.99 mg/mL (ultrasonic; warming; adjust pH to 3 with 1 M HCl; heat to 60°C)

Smiles

CC1=[N+](C2=CC=CC=C2C(N)=C1)CCCCCCCCCC[N+](C3=CC=CC=C3C(N)=C4)=C4C.[Cl-].[Cl-]

Molecular Formula

C30H40Cl2N4

Molecular Weight

527.57

Precautions

H302, H315, H319, H335

References & Citations

[1]Kramer, W., [Treatment of tonsillitis with dequalinium chloride]. Fortschr Med, 1977. 95 (16) : p. 1108-10.|[2]Gamboa-Vujicic, G., et al., Toxicity of the mitochondrial poison dequalinium chloride in a murine model system. J Pharm Sci, 1993. 82 (3) : p. 231-5.|[3]Belanger-Coast MG, et al. Dequalinium chloride is an antagonists of α7 nicotinic acetylcholine receptors. Eur J Pharmacol. 2022 Jun 15;925:175000.|[4]Mendling W, et al. Use of locally delivered dequalinium chloride in the treatment of vaginal infections: a review. Arch Gynecol Obstet. 2016 Mar;293 (3) :469-84.|[5]Castle NA, et al. Dequalinium: a potent inhibitor of apamin-sensitive K+ channels in hepatocytes and of nicotinic responses in skeletal muscle. Eur J Pharmacol. 1993 May 19;236 (2) :201-7.|[6]Bugay V, et al. Effects of Sublethal Organophosphate Toxicity and Anti-cholinergics on Electroencephalogram and Respiratory Mechanics in Mice. Front Neurosci. 2022 May 2;16:866899.|[7]Abdul M, et al. Expression and activity of potassium ion channels in human prostate cancer. Cancer Lett. 2002 Dec 1;186 (1) :99-105.