GSK854
GSK854 is a potent Inhibitor of Troponin I-Interacting Kinase (TNNI3K) . GSK854 is a suitable lead for identifying new cardiac medicines and have been employed as in vivo tools in investigational studies aimed at defining the role of TNNI3K within heart failure[1].
Product Specifications
CAS Number
[1316059-00-3]
UNSPSC
12352005
Target
MAP3K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gsk854.html
Concentration
10mM
Purity
99.73
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(C(NC2=NC=NC(NC3=NC=C(C=C3)Cl)=C2)=C1)S(=O)(CC)=O)(NC)=O
Molecular Formula
C18H19ClN6O4S2
Molecular Weight
482.96
References & Citations
[1]Philp J, et al. 4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors. J Med Chem. 2018;61 (7) :3076-3088.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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