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PD-1/PD-L1-IN-41

PD-1/ PD-L1-in-41 (Compound 5c) is a PD-L1 and PD-1 inhibitor with IC50 value of 10.2 nM[1].

Product Specifications

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pd-1-pd-l1-in-41.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C=CC=C1C2=CC=C3OCCOC3=C2)COC4=CC(OCC5=CC(C#N)=NC=C5)=C(CN(CCO)C)C=C4Cl

Molecular Formula

C33H32ClN3O5

Molecular Weight

586.08

References & Citations

[1]Bamminger K, et al. Development and In Vivo Evaluation of Small-Molecule Ligands for Positron Emission Tomography of Immune Checkpoint Modulation Targeting Programmed Cell Death 1 Ligand 1. J Med Chem. 2024;67 (5) :4036-4062.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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