CCR4 antagonist 3
CCR4 antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC50 value of 1.7 μM for [125I]TARC (thymus and activation regulated chemokine) . CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM) [1].
Product Specifications
CAS Number
[1957-01-3]
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ccr4-antagonist-3-1.html
Purity
99.94
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CC1=CSC(NC2=C3C=CC=CC3=CC=C2)=N1
Molecular Formula
C14H12N2S
Molecular Weight
240.32
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Wang X, et al. Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16 (10) :2800-3.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR4
Available Sizes
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