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BMP agonist 2

BMP agonist 2 (derivative I-9) is a potent bone-inducing cytokine. BMP agonist 2 promotes bone tissue production by increasing the proportion and activity of osteoblasts. BMP agonist 2 promotes osteoblast proliferation and differentiation through the BMP2-ATF4 signaling axis, in which ATF4 is a transcription factor closely related to osteoblast differentiation and bone formation. BMP agonist 2 can be used in the study of senile osteoporosis (SOP) [1].

Product Specifications

CAS Number

1438900-88-9

UNSPSC

12352005

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/bmp-agonist-2.html

Purity

99.26

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC2=CC=C(OC)C=C2O1)OCCN3CCOCC3

Molecular Formula

C16H19NO5

Molecular Weight

305.33

References & Citations

[1]Zhou Z, et al. Efficacy, Mechanism, and Structure–Activity Relationship of 6-Methoxy Benzofuran Derivatives as a Useful Tool for Senile Osteoporosis[J]. Journal of Medicinal Chemistry, 2023, 66 (3) : 1742-1760.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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