Keap1 (NM_001110307) Mouse Recombinant Protein
Product Specifications
Background
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
INRF2; mKIAA0132
Gene ID
50868
UniProt
Q9Z2X8
Accession Number mRNA
NM_001110307
Chromosomal Location
9 A3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
69.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Keap1
Species
Mouse
Protein ID
NP_001103777
Overview
Purified recombinant protein of Mouse kelch-like ECH-associated protein 1 (Keap1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/50868
Uniprot URL
https://www.uniprot.org/uniprot/Q9Z2X8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001110307
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001103777
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