Sarm1 (NM_172795) Mouse Recombinant Protein
Product Specifications
Background
Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38. Can restrict West Nile virus (WNV) pathogenesis.[UniProtKB/Swiss-Prot Function]
Synonyms
A830091I15Rik; C78606; MyD885; Sarm
Gene ID
237868
UniProt
Q6PDS3
Accession Number mRNA
NM_172795
Chromosomal Location
11 46.74 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
80.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Sarm1
Species
Mouse
Protein ID
NP_766383
Overview
Purified recombinant protein of Mouse sterile alpha and HEAT/Armadillo motif containing 1 (Sarm1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/237868
Uniprot URL
https://www.uniprot.org/uniprot/Q6PDS3
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_172795
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_766383
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