Dis3l2 (NM_153530) Mouse Recombinant Protein
Product Specifications
Background
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.[UniProtKB/Swiss-Prot Function]
Synonyms
4930429A22Rik; 8030493P09Rik
Gene ID
208718
UniProt
Q8CI75
Accession Number mRNA
NM_153530
Chromosomal Location
1 C5
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
97.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Dis3l2
Species
Mouse
Protein ID
NP_705758
Overview
Purified recombinant protein of Mouse DIS3 like 3'-5' exoribonuclease 2 (Dis3l2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/208718
Uniprot URL
https://www.uniprot.org/uniprot/Q8CI75
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_153530
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_705758
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