SPG21 (NM_016630) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Synonyms
ABHD21; ACP33; BM-019; GL010; MAST
Gene ID
51324
UniProt
Q9NZD8, A0A024R5Y1
Accession Number mRNA
NM_016630
Chromosomal Location
15q22.31
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
34.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SPG21
Species
Human
Protein ID
NP_057714
Overview
Recombinant protein of human spastic paraplegia 21 (autosomal recessive, Mast syndrome) (SPG21), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/51324
Uniprot URL
https://www.uniprot.org/uniprot/Q9NZD8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_016630
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_057714
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