PNPO (NM_018129) Human Recombinant Protein

Product Specifications

Background

The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy. [provided by RefSeq, Oct 2008]

Overview

Recombinant protein of human pyridoxamine 5'-phosphate oxidase (PNPO)

Synonyms

HEL-S-302; PDXPO

Gene ID

55163

UniProt

Q9NVS9, V9HW45

Accession Number mRNA

NM_018129

Chromosomal Location

17q21.32

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Metabolic pathways, Vitamin B6 metabolism

Field of Research

Metabolic pathways, Vitamin B6 metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

29.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.