PNPO (NM_018129) Human Recombinant Protein
Product Specifications
Background
The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy. [provided by RefSeq, Oct 2008]
Synonyms
HEL-S-302; PDXPO
Gene ID
55163
UniProt
Q9NVS9, V9HW45
Accession Number mRNA
NM_018129
Chromosomal Location
17q21.32
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Metabolic pathways, Vitamin B6 metabolism
Field of Research
Metabolic pathways, Vitamin B6 metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
29.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PNPO
Species
Human
Protein ID
NP_060599
Overview
Recombinant protein of human pyridoxamine 5'-phosphate oxidase (PNPO)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/55163
Uniprot URL
https://www.uniprot.org/uniprot/Q9NVS9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_018129
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_060599
Curated Selection
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