TOLLIP (NM_019009) Human Recombinant Protein
Product Specifications
Background
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Overview
Recombinant protein of human toll interacting protein (TOLLIP)
Synonyms
IL-1RAcPIP
Gene ID
54472
UniProt
Q9H0E2, Q6FIE9
Accession Number mRNA
NM_019009
Chromosomal Location
11p15.5
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Toll-like receptor signaling pathway
Field of Research
Toll-like receptor signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
30.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TOLLIP
Species
Human
Protein ID
NP_061882
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/54472
Uniprot URL
https://www.uniprot.org/uniprot/Q9H0E2
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_019009
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_061882
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