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HSP70-1A (HSPA1A) (NM_005345) Human Recombinant Protein

Product Specifications

Background

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human heat shock 70kDa protein 1A (HSPA1A)

Synonyms

HEL-S-103; HSP70-1; HSP70-1A; HSP70-2; HSP70.1; HSP70.2; HSP70I; HSP72; HSPA1

Gene ID

3303

UniProt

P08107, P0DMV8, P0DMV9, A8K5I0, B3KTT5

Accession Number mRNA

NM_005345

Chromosomal Location

6p21.33

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Antigen processing and presentation, Endocytosis, MAPK signaling pathway, Prion diseases, Spliceosome

Field of Research

Antigen processing and presentation, Endocytosis, MAPK signaling pathway, Prion diseases, Spliceosome

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

Higher specific activity than E. coli derived HSP70: Origene human recombinant Hsp70 was compared side-by-side with E. coli derived Hsp70 in a firefly luciferase refolding assay. Percentage of refolding is relative to an identical load of non-denatured luciferase in the reaction. The human cell produced Hsp70 is approximately 30% more active than the bacterial produced Hsp70

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

69.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

HSPA1A

Species

Human

Protein ID

NP_005336

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3303

Uniprot URL

https://www.uniprot.org/uniprot/P08107

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_005345

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_005336

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