STUB1 (NM_005861) Human Recombinant Protein
Product Specifications
Background
This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]
Synonyms
CHIP; HSPABP2; NY-CO-7; SCA48; SCAR16; SDCCAG7; UBOX1
Gene ID
10273
UniProt
Q9UNE7
Accession Number mRNA
NM_005861
Chromosomal Location
16p13.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Ubiquitin mediated proteolysis
Field of Research
Ubiquitin mediated proteolysis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
34.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
STUB1
Species
Human
Protein ID
NP_005852
Overview
Recombinant protein of human STIP1 homology and U-box containing protein 1 (STUB1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10273
Uniprot URL
https://www.uniprot.org/uniprot/Q9UNE7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005861
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005852
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