Lysyl tRNA synthetase (KARS) (NM_005548) Human Recombinant Protein
Product Specifications
Background
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human lysyl-tRNA synthetase (KARS), transcript variant 2
Synonyms
CMTRIB; DFNB89; KARS1; KARS2; KRS
Gene ID
3735
UniProt
Q15046
Accession Number mRNA
NM_005548
Chromosomal Location
16q23.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Aminoacyl-tRNA biosynthesis
Field of Research
Aminoacyl-tRNA biosynthesis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
67.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
KARS
Species
Human
Protein ID
NP_005539
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3735
Uniprot URL
https://www.uniprot.org/uniprot/Q15046
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005548
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005539
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