PAFAH2 (NM_000437) Human Recombinant Protein
Product Specifications
Background
This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) . However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008]
Synonyms
HSD-PLA2
Gene ID
5051
UniProt
Q99487
Accession Number mRNA
NM_000437
Chromosomal Location
1p36.11
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Ether lipid metabolism, Metabolic pathways
Field of Research
Ether lipid metabolism, Metabolic pathways
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
43.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PAFAH2
Species
Human
Protein ID
NP_000428
Overview
Recombinant protein of human platelet-activating factor acetylhydrolase 2, 40kDa (PAFAH2)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5051
Uniprot URL
https://www.uniprot.org/uniprot/Q99487
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000437
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000428
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