Cathepsin H (CTSH) (NM_004390) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Synonyms
ACC-4; ACC-5; ACC4; ACC5; CPSB
Gene ID
1512
UniProt
P09668
Accession Number mRNA
NM_004390
Chromosomal Location
15q25.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Lysosome
Field of Research
Lysosome
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Protease
Molecular Weight
35.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CTSH
Species
Human
Protein ID
NP_004381
Overview
Recombinant protein of human cathepsin H (CTSH), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1512
Uniprot URL
https://www.uniprot.org/uniprot/P09668
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004390
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004381
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