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Cathepsin H (CTSH) (NM_004390) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Synonyms

ACC-4; ACC-5; ACC4; ACC5; CPSB

Gene ID

1512

UniProt

P09668

Accession Number mRNA

NM_004390

Chromosomal Location

15q25.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Lysosome

Field of Research

Lysosome

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protease

Molecular Weight

35.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

CTSH

Species

Human

Protein ID

NP_004381

Overview

Recombinant protein of human cathepsin H (CTSH), transcript variant 1

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/1512

Uniprot URL

https://www.uniprot.org/uniprot/P09668

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_004390

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_004381

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