Neuraminidase (NEU1) (NM_000434) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein') . Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008]
Synonyms
NANH; NEU; SIAL1
Gene ID
4758
UniProt
Q99519, Q5JQI0
Accession Number mRNA
NM_000434
Chromosomal Location
6p21.33
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Lysosome, Other glycan degradation, Sphingolipid metabolism
Field of Research
Lysosome, Other glycan degradation, Sphingolipid metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
29118338
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
40.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NEU1
Species
Human
Protein ID
NP_000425
Overview
Recombinant protein of human sialidase 1 (lysosomal sialidase) (NEU1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4758
Uniprot URL
https://www.uniprot.org/uniprot/Q99519
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000434
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000425
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