TGFBI (NM_000358) Human Recombinant Protein
Product Specifications
Background
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human transforming growth factor, beta-induced, 68kDa (TGFBI)
Synonyms
BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; LCD1
Gene ID
7045
UniProt
Q15582, A0A0S2Z4Q2
Accession Number mRNA
NM_000358
Chromosomal Location
5q31.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Secreted Protein, Transmembrane
Molecular Weight
72.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TGFBI
Species
Human
Protein ID
NP_000349
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7045
Uniprot URL
https://www.uniprot.org/uniprot/Q15582
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000358
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000349
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