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Nck beta (NCK2) (NM_001004720) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human NCK adaptor protein 2 (NCK2), transcript variant 2

Synonyms

GRB4; NCKbeta

Gene ID

8440

UniProt

O43639, A0A0S2Z4M6

Accession Number mRNA

NM_001004720

Chromosomal Location

2q12.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Axon guidance, ErbB signaling pathway, Pathogenic Escherichia coli infection, T cell receptor signaling pathway

Field of Research

Axon guidance, ErbB signaling pathway, Pathogenic Escherichia coli infection, T cell receptor signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

42.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

NCK2

Species

Human

Protein ID

NP_001004720

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/8440

Uniprot URL

https://www.uniprot.org/uniprot/O43639

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001004720

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001004720

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